The reference site for Promethazine

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties.

WHAT IS PROMETHAZINE?

Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. This medication is used to treat allergic symptoms and reactions such as itching, runny nose, sneezing, itchy and watery eyes, hives, and itchy skin rashes.

Additionally, promethazine is also used to cause sedation (sleep), to assist in controlling postoperative pain, to control nausea and vomiting (especially after surgery), and to prevent motion sickness.

Some of its brand names equivalents include Phenergan® and Promethegan®.

 

Brand Name(s): Phenergan; Promethega; Promacot; Promethazine HCl Syrup
CAS nº: 60-87-7
(proe meth’ a zeen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to promethazine and its correct use. Please read them carefully.

FDA Information

Promethazine HCI was approved by the FDA in 1951 and is used to treat hay fever, allergy-related stuffy or runny nose, and other minor allergies.

It is a prescription drug in the United States, but is available over the counter in the United Kingdom, Switzerland, and many other countries (in its brand name forms Phenergan® and Promethegan®).

Why is this medication prescribed?

Promethazine is an antihistamine. It works by blocking the effects of the naturally occurring chemical histamine in your body.

Promethazine is used to treat allergic symptoms and reactions such as itching, runny nose, sneezing, itchy and watery eyes, hives, and itchy skin rashes.

Promethazine is also used to cause sedation (sleep), to assist in controlling postoperative pain, to control nausea and vomiting (especially after surgery), and to prevent motion sickness.

Other uses for this medicine

Promethazine can be used to increase the activity of opioids. It allows lower opioid doses and decreases their emetic properties.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Promethazine comes as a tablet, oral liquid, and rectal suppository.

Tablets may be taken with or without food.

Suppositories are unwrapped and moistened with water before insertion into the rectum, and try to empty your bowel and bladder just before usage. It may be best to use this medicine at bedtime.

Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down after inserting it and hold in the suppository for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after you have inserted the suppository.

Take promethazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

BEFORE TAKING PROMETHAZINE:

Please inform your doctor and pharmacist if you are allergic to promethazine or any other drugs.

Always tell your doctor and pharmacist what prescription and non-prescription medications you are taking, especially medications for depression, seizures, colds, allergies, muscle relaxants, pain medication, sedatives, sleeping pills, tranquilizers, and vitamins.

Tell your doctor if you have or have ever had difficulty urinating (due to an enlarged prostate), glaucoma, epilepsy (seizures), ulcers, asthma or lung disease, high blood pressure, or heart or liver disease.

Before giving promethazine to a child, tell the doctor and pharmacist if you have a family history of sudden infant death syndrome (crib death) or if you regularly have difficulty waking the child.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking promethazine, call your doctor.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine.

You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.

Remember that alcohol can add to the drowsiness caused by this drug.

Finally, inform your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and take only your next regularly scheduled dose.

Never take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

Side effects from promethazine may include:

drowsiness
changes in blood pressure
skin reactions
blood cell changes
breathing problems

Tell your doctor if any of these symptoms are severe or do not go away:

dry mouth
drowsiness
confusion
fatigue
difficulty coordinating movements
stuffy nose

If you experience any of the following symptoms, call your doctor immediately:

vision problems
ringing in the ears
tremors
insomnia
excitement
restlessness
yellowing of the skin or eyes
skin rash
hives
swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles or lower legs
hoarseness
difficulty breathing or swallowing

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed, and it is advised that you talk with your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

severe drowsiness
dizziness
dry mouth
large pupils
flushing
nausea
vomiting
difficulty breathing
unconsciousness

Product Images

PICTURES OF PROMETHAZINE PILLS

Below you will find images and specific information on the principal types of promethazine that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PROMETHAZINE
Strength(s): 12.5 MG
Imprint: A 405
Manufacturer: ABLE LABS, INC.

Name: PHENERGAN
Strength(s): 25 MG
Imprint: WYETH 27
Manufacturer: WYETH PHARM.

Name: PROMETHAZINE
Strength(s): 25 MG
Imprint: GG 225
Manufacturer: SANDOZ

Name: PROMETHAZINE
Strength(s): 25 MG
Imprint: DAN DAN | 5307
Manufacturer: WATSON LABS.

Name: PHENERGAN
Strength(s): 50 MG
Imprint: WYETH 227
Manufacturer: WYETH PHARM.

Name: PROMETHAZINE
Strength(s): 50 MG
Imprint: GG 235
Manufacturer: SANDOZ

Name: PROMETHAZINE
Strength(s): 50 MG
Imprint: DAN 5319
Manufacturer: WATSON LABS.

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